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Microspheres of Diltiazem HCl as a Novel Drug Delivery by Sachin Chauhan, Ankur Javia, Avinash Kumar Seth (Paperback, 2012)

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Product Information

The present study was an attempt to develop microspheres for diltiazem HCl using three different polymers. Diltiazem HCl, being a hydrophilic drug was entrapped in the microspheres by w/o solvent evaporation method. To optimize the weight of polymer, totally five batches were prepared for each of the polymer and various evaluation parameters were studied. The ratio 1:2 (i.e. formulation ERS4) shows highest production yield, drug content and percentage entrapment among the all formulations. FTIR and XRD analysis was also carried out for pure drug and drug containing ethylcellulose, eudragit RS 100 and eudragit RL 100 microspheres, which shows there were no drug-polymer interaction. Based on these test, ERS4 was chosen as the best formulation. Then for all the formulations, in vitro release study was carried out for eight hrs. Which shows the formulation ERS4 and ERS5 having much prolonged release compare to remaining formulations. Dissolution data were fitted to different mathematical models, which follows the diffusion controlled release mechanism from all prepared batches.

Product Identifiers

Publisher
LAP
ISBN-13
9783659153457
eBay Product ID (ePID)
138601803

Product Key Features

Author
Sachin Chauhan, Ankur Javia, Avinash Kumar Seth
Publication Name
Microspheres of Diltiazem Hcl As a Novel Drug Delivery
Format
Paperback
Language
English
Subject
Medicine
Publication Year
2012
Type
Textbook
Number of Pages
88 Pages

Dimensions

Item Height
229mm
Item Width
152mm
Item Weight
141g

Additional Product Features

Title_Author
Sachin Chauhan, Avinash Kumar Seth, Ankur Javia
Country/Region of Manufacture
Germany

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Microspheres of Diltiazem HCl as a Novel Drug Delivery by Sachin Chauhan, Ankur Javia, Avinash Kumar Seth (Paperback, 2012)

Best-selling in Adult Learning & University

Secrets Of Mental Math: The Mathemagician's Guide to Lightening Calculation and Amazing Maths Tricks by Arthur Benjamin, Michael Shermer (Paperback, 2006)

The Falsification of History: Our Distorted Reality by John Hamer (Paperback, 2013)

Code of Practice for In-service Inspection and Testing of Electrical Equipment by The Institution of Engineering and Technology (Paperback, 2020)

Never Split the Difference: Negotiating as if Your Life Depended on It by Chris Voss, Tahl Raz (Paperback, 2017)

Weapons of Mass Instruction: A Schoolteacher's Journey Through the Dark World of Compulsory Schooling by John Taylor Gatto (Paperback, 2010)

Adult Children of Emotionally Immature Parents: How to Heal from Distant, Rejecting, or Self-Involved Parents by Lindsay C Gibson (Paperback, 2015)

Die with Zero: Getting All You Can from Your Money and Your Life by Bill Perkins (Paperback, 2021)

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